Noah Centineo is best known for his roles in the final three seasons of the television series The Fosters, the television film How to Build a Better Boy, and the 2018 Netflix romantic comedy films To All the Boys I've Loved Before and Sierra Burgess Is a Loser. He can also be seen starring in the Netflix hit spy show, The Recruit, playing the lead role of "Brooks Rattigan" in The Stand-In, "Lance Black" in Swiped, and co-starring in the Charlie's Angels film.

In 2009, Centineo starred as the lead, Josh Peters, in the family film The Gold Retrievers. He then had small roles in the Disney Channel sitcoms Austin & Ally and Shake It Up. Centineo subsequently co-starred as Jaden Stark in the Disney Channel romantic comedy film How to Build a Better Boy. In 2015, he took over the main role of Jesus Adams Foster in Freeform's drama series The Fosters. In 2017, Centineo was nominated for the Teen Choice Award for Choice Summer TV Star: Male for his performance.

In 2017, Centineo began starring as Hawk in go90's teen drama-thriller series T@gged, and portrayed surfer/artist Johnny Sanders Jr. in the coming-of-age romantic comedy film SPF-18. That same year, he appeared as Camila Cabello's love interest in the music video for her single "Havana."